Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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EFFECTS OF DRY ROOT EXTRACT SCUTELLARIA BAICALENSIS GEORGI ON DEVELOPMENT OXIDATIVE STRESS INDUCED BY CYCLOPHOSPHAMIDE

Potapova A.A. 1 Dorkina E.G. 1 Sergeeva E.O. 1 Sadzhaja L.A. 1
1 Pyatigorsk medico-pharmaceutical institute – branch of the Volgograd state medical university
Hepato-and nephrotoxic effects of cyclophosphamide, as other cytotoxic drugs, which mainly depends on the intensification of processes lipid peroxidation determines the prospects of using a complex anticancer chemotherapy drugs with antioxidant action drug , promising plant in this respect is the Scutellaria baicalensis. Experiments on rats studied efficiency of the dry extract Scutellaria baicalensis, urokam, legalon with liver and kidney damage cyclophosphamide. Found that after a single administration of cyclophosphamide oxidative stress occurs . Dry extract at a dose of 300 mg / kg by oral administration is most effective than the reference drugs urokam and legalon inhibits lipid peroxidation and restores the activity of the endogenous enzymes antioxidant defense system during intoxication cyclophosphamide.