Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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EFFECTIVENESS OF THERAPY OF NON-HODGKIN LYMPHOMA WITH BONE MARROW LESION BY FLOW CYTOMETRY

Pushkareva T.F. 1 Lysenko I.B. 1 Novikova I.A. 1 Kozuk O.V. 1 Novoselova K.A. 1
1 Federal State Budget Institution “Rostov Research Oncologic Institute” Ministry of Health of Russia
One of the important mechanisms of онко.. is the violation of programmed cell`s death – apoptosis. That`s why the actual task is the study of predictive level`s significance ofexpressing bcl-2 in the cells in order to choose strategy of chemotherapy. Modern reports of chemo- and/or immunotherapy can lead to total elimination of tumor cells, that let ascertain patient`s absence minimal residual disease. The determination of left tumor clone and экспресии Bcl-2 by the method of flow cytometry let figure out next - the residual tumor clone of patients, what were examined with a system chemotherapy, decreased in 5,1 comparing with content tumor cells before therapy(p≤0,05) . The tumor clone among the patients who got the automielohimioterapia, decreased in 8.8 comparing with the amount of tumor cells before the treatment started (p≤0,05). Besides, the reliable distinction of exponent of percentile content of tumor cells in the groups of patients after caring out СХТиАМХТ was remarked. The cell`s study, expressing antigen bcl-2, before therapy and after carrying out 2 courses of system chemotherapy andautomielohimioterapia showed that the percentage of cells expressing bcl-2 before the therapy was equal to 43,8+2,7%, after 2 courses of the significant decrease of those cells was remarked.