Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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EFFECT OF UREMIC FACTORS ON PERIPHERAL VASCULAR REMODELING IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Pyankina O.V. 1 Tatarintsev P.B. 2 Ragozin O.N. 1
1 Khanty-Mansiysk State Medical Academy
2 Ugra State University
The examination of 84 patients in various stages of chronic kidney disease and 16 healthy volunteers, the comparison group, analyzed the combined contributions of the risk factors of cardiovascular complications associated with uremia, on the structural and functional changes in the vessels of the lower extremities, the common carotid arteries. In CKD structural and functional changes in peripheral vessels (thickness of the intima-media brachiocephalic vessels increase - 34.5%, calcification brachiocephalic vessels – 12%, pathological changes ABI – 28.6 %) are registered in the predialysis phase of chronic renal failure. The detection rate of thickening of the intima-media brachiocephalic vessels increases with a decrease in glomerular filtration rate (GFR), correlates with the severity of anemia (r = -0,46, p <0.0001). ABI value changes in the early stages of chronic renal failure, parallel disturbances of calcium-phosphorus metabolism (PхCa r = 0,64, p <0,001; PTH r = 0,48, p <0,001).