Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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STUDY OF THE EFFECTIVENESS OF POLYMER-CONJUGATED FORM OF ANTICANCER DRUG PROSPIDIN IN RATS WITH TRANSPLANTED SEIDELS HEPATOMA

Pyataev N.A. 1 Kladiev A.A. 2 Kokorev A.V. 1 Minaeva O.V. 1 Zyrnyaeva N.N. 1 Stolyarov G.S. 1 Firstov A.A. 1 Saushev I.V. 1 Firstov S.A. 1 Evseev R.M. 1
1 Mordovia State University
2 Biotechnological company TNK
Antitumor activity of Prospidin in two forms (soluble and conjugated with dextran phosphate) in rats with transplanted Seidel’s hepatoma was investigated. The following indicators was used as markers of efficiency and toxicity: increase in lifetime, the absolute and relative weight of ascites, amount of hepatoma cells in ascites, complete blood count and biochemical parameters of blood. Prospidin was found to have dose-dependent antitumor effect. The optimal dose for soluble prospidina and prospidin-hydrogel is 450 mg/kg. Antitumor activity of Prospidin conjugated with dextran phosphate is 2-3 times higher than the same parameter of soluble drug. Side effects of Prospidin were noticeable starting from a dose of 1350 mg/kg. Leukopenia, thrombocytopenia, hepatosis and nephropathy were typical for soluble Prospidin. Enterocolitis or ileus were frequent side effects for Prospidin-hydrogel.