Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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STUDY OF CYTOKINE LEVELS IN BIOLOGOCAL FLUIDS OF BACTERIA CARRIERS

Boiko O.V. 1 Akhmineeva A.K. 1 Gudinskaya N.I. 1 Aleksashina L.I. 2
1 Astrakhan State Medical Academy
2 Astrakhan State University
The article analyzes interleukin status for staphilococcus bacteria carrying. The most notable changes were found at the persistence of Staphylococcus aureus. The reaction of the patient to the implementation of this type of microorganisms is accompanied by a predominance of anti-inflammatory mechanisms that allow microbial cells to settle in macroorganism. It is found that the introduction of Staphylococcus aureus causes, along with an normal increase in IL-8, IL pronounced abnormal growth of 10, which allows the bacteria to avoid opsonization and phagocytosis. Is located intracellularly resident strains do not cause such changes, and the ratio of pro-and anti-inflammatory cytokines few normal. Perhaps this is due to the fact that the resident carrier is characterized by an intracellular location of the pathogen, which excludes its close contact with the immune system and, as a consequence, its constant stimulation. Carriers S.epidermidis IL reaction is somewhat different, but also noted the growth of IL 10. The constant presence of this species in resident aureus carriers associated with proinflammatory cytokine growth – IL-8, which is logical since S.epidermidis from the literature, unlike S.aureus, does not possess a variety of shielding structures that impede its recognition by the immune system persistent infection.