Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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EARLY CLINICAL AND IMMUNOLOGICAL EFFECTS INTERFERON-α2β IN COMPLEX THERAPY OF NEWBORNS WITH THE SYNDROME OF THE MAGNIFICATION THYMIC GLAND

Svinareva М.G. 1 Kleshchenko E.I. 1 Kolesnikova N.V. 1
1 Kuban state medical university Ministries of Health of Russia
In work the estimation clinical and immunological efficiency interferon -α2β (Viferon) in structure of traditional therapy at newborns with a syndrome of the magnification thymic gland (SMTE) and clinico-laboratory displays of a fetal infection (PIC) is lead. It is shown, that at newborns with SMTG statistically significant depression of production of cytokines is characteristic, in a greater degree - proinflammatory (IL-1, IL-6, IFN, IL-2), that has found confirmation in authentic decrease of size of a proinflammatory index (PII) concerning those at children with PIC without attributes SMTG, and also oppression of phagocytic function of neutrocytes. Clinically these changes were accompanied by attributes mix-infection (a congenital pneumonia with a conjunctivitis or vezikulopustulesis) on a background of a syndrome of the increased nervously-reflex excitability. Including in traditional therapy of newborns with SMTG and PIC interferon -α2β allows to observe positive clinical and immunomodulation effects in early (14 days from the beginning of therapy) terms of observation when the authentic tendency to normalization of investigated parameters takes place.