Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CLINICAL AND PATHOGENETIC SIGNIFICANCE OF DISLIPIDEMIA DETERMINATION IN OSTEOARTHRITIS

Simakova E.S. 1 Sivordova L.E. 1 Polyakova J.V., Zborovsky A.B. 1 Zavodovsky B.V. 1
1 Research Institute for clinical and experimental rheumatology
We obtained data on clinical and pathogenetic significance of the level of oxidized low-density lipoprotein (oLDL) and their antibodies (anti-oLDL) in osteoarthritis (OA). оLDL and anti-oLDL determination was performed with enzyme immunoassay (ELISA-test) before and after treatment. To assess the state of the joints we used indexes WOMAC, Lequesne gonarthrosis and coxarthrosis, Dreiser index for osteoarthritis of brushes. Pain intensity, duration, and severity of stiffness and functional ability of the patient were assessed by visual analog scale. In the study of 130 patients with OA we noted elevated levels oLDL and their antibodies in the sera of 60 and 29 % of patients respectively. Increased concentrations were associated with more severe OA. We assume that this is due to damage of biopolymers that form cell membranes and tissues around the cartilage. In our study patients with high levels of the oLDL and anti-oLDL had forms of the disease with more severe radiographic and functional changes in the joints. Thus, it can be assumed that oxidized low-density lipoproteins and antibodies to them play an important role in the pathogenesis of osteoarthritis.