Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ROLE OF NA+, K+, 2CL- - COTRANPORT IN MECHANISMS OF VASOCONSTRICTIVE ACTION OF HYDROGEN SULFIDE

Smagliy L.V. 1
1 Siberian state medical university
Mechanisms of vasoconstrictive action of the donor of hydrogen sulfide sodium hydrosulfide were investigated with a method of mechanography on endothelium-denuded segments of the white rats thoracic aorta, and with radionuclide method using freshly isolated smooth muscle cells from the same object. In low concentrations (up to 100 µM) the sodium hydrosulfide increased the mechanical tension of vascular segments precontracted with highpotassium solution, and in high concentrations (500-1000 µM) sodium hydrosulfide caused a relaxation. Sodium hydrosulfide in concentrations up to 100 µM stimulated inward-directed bumetanide-sensitive transport of 86Rb in isolated smooth muscle cells. This data suggest that constrictive action of low concentrations of hydrogen sulfide on vascular segments is a consequence of activation of Na+, K+, 2Cl- -cotransport.