Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN LIGHT OF CYTOKINE PROFILE CHANGES

Smetneva N.S. 1 Popkova A.S. 1 Samoylova N.V. 1 Bondarets O.V. 1 Kukharenok M.V. 2 Vakhrushkina O.E. 2 Malyshev I.Y. 1 Popkova A.M. 1
1 GBOU VPO «Moscow State University of Medicine and Dentistry named after A.I.Evdokimov»
2 GBUZ «GKB number 70 DMD»
COPD is one of the most important public health problems, and the severity of COPD depends not only on the severity of obstructive disorders, and severity of respiratory symptoms, but also on the presence of extrapulmonary manifestations and comorbidities. Endothelial dysfunction is a common link in diseases of the cardiovascular and chronic obstructive pulmonary disease, and chronic persistent systemic inflammation plays an important role in the pathogenesis of atherosclerosis. In the study of the pathogenesis of endothelial dysfunction has revealed the role of the same pro-inflammatory cytokines, which contribute significantly to the development of COPD and its complications. Objective of this study was to evaluate endothelial dysfunction in COPD patients according to the severity of the disease and severity of inflammation according to the cytokine profile. Conclusions: The reaction of the brachial artery to reactive hyperemia is strongly correlated with the degree of COPD. At the same time, we have found a significant influence on the development of endothelial dysfunction with pro-inflammatory cytokines of the complex.