Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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FEATURES OF STRUCTURAL CHANGES THE BRAIN IN MODELING ALIMENTARY MAGNESIUM DEFICIENCY

Smirnov A.V. 1 Snigur G.L. 1 Shmidt M.V. 1 Gurov D.Y. 1 Evsyukov O.Y. 1 Mednikov D.S. 1 Spasov A.A. 1 Kharitonova M.V. 1
1 Volgograd State Medical University
In this article it was presented the results qualitative and quantitative study of the structural changes in various parts of the rat’s brain in the modeling of nutritional magnesium deficiency. It was noted that the changes expression of proteins TRPM7, TRPM6, the inducible and endothelial nitric oxide synthase in neurons and neuropil of the hypothalamus, hippocampus, cerebral cortex with magnesium deficiency 8 and 12 weeks showed the predominance an alteration to adaptive changes. Atrophic changes in the neurosecretory cells of the magnocellular nuclei of the hypothalamus combined with signs of reversible damage in deficiency of magnesium at 8 and 12 weeks at different levels of pathological studies, developing against the background to alterative changes in brain’s capillaries and blood circulation disorders.