Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

CHANGES OF SERUM PROTEIN IN PATIENTS WITH ACUTE ALCOHOLIC PSYCHOSIS

Solovieva N.V. 1 Shidakova N.A. 2 Soloviev A.G. 1
1 State budgetary institution of higher professional education “Northern state medical university of Ministry of Healthcare of the Russian Federation”
2 Federal state budgetary health care institution “Northern Medical Clinical Center named after Semashko of Federal Medical-Biological Agency”
State of acute alcoholic psychosis (AAP) in patients with alcohol dependence syndrome (ADS) is characterized by the severe disruption of protein-synthetic function of the liver. The study of the content of total protein, albumins, globulin fractions, components of the complement system, C-reactive protein in patients with substance abuse in the state of the AAP was conducted. At the height of an acute psychotic state against reduction of total protein and albumins there is an increase in globulin fractions, α-1, α-2, γ-globulins, and C-reactive protein (CRP). In the dynamics of CAP relief there observed increased levels of albumin, with recorded maximum values of α-, β-and γ-globulins, C3, C4 fractions of complement, but the decrease of CRP. Increased level of acute phase proteins (BOP) and proteinogram features meet the signs of acute inflammatory syndrome. Features of the protein fractions of blood serum with BOP content increase justify the acute inflammation syndrome allocation in addicted patients in a state of AAP.