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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
INFLUENCE OF EXPERIMENTAL ENDOGENOUS AND EXOGENOUS HYPERPROLAKTINEMY ON WATER SECRETORY FUNCTION OF KIDNEYS
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Of prolactin as a hormone it is known much and long ago, especially of its endocrine properties, and in its communications with other systems and participation in many processes of activity lately become clear. At the same time it is impossible to give a definite answer to a question of its influence on functions of kidneys and a water-salt exchange. Studying of influence of a hyperprolactinemia on diuresis and the main processes of uropoiesis, and in the presence of changes, opening of the mechanisms lying in their basis was the purpose of our work. On Wistar rats were created the experimental models of a endogenous hyperprolactinemia (per os introduction within 22 days of a blocker of D2 of receptors – a haloperidol in a dose of 0,2 mg/100g) and exogenous hyperprolactinemia (in/m introduction of lactin within seven days in a dose of 9 pieces / 100г). Intake of a haloperidol causes progressing decrease of water diuresis, owing to increase of tubular reabsorption of water, at invariable speed of a glomerular filtration. Introduction lactin causes similar changes. Increase of a tubular reabsorption of water is caused by growth of an osmotic gradient in layers of kidneys because of increase of the content of urea and sodium. These effects of lactin have temporary functional character, and similarity of changes within long introduction of a haloperidol and lactin allows to consider that they are caused by an endogenous hyperprolactinemia.