Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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EVALUATION OF THE FUNCTIONAL-METABOLIC STATUS OF THE MYOCARDIUM IN ENDOTOXEMIA

Tarasova T.V. 1 Satybaldin O.A. 2 Chibisov S.M. 2 Leshchankin N.Y. 1 Saushev I.V. 1 Harlitskaya E.V. 2
1 Ogarev Mordovia State University
2 Russian people friendship university
This paper discusses some of the mechanisms of myocardial damage during the development of endogenous intoxication, peritoneal origin. The basis of the experimental work were studies conducted on 10 adult mongrel adult dogs that simulated fecal peritonitis. Received laboratory-diagnostic indicators showed the development of endogenous intoxication. It is shown that in case of peritonitis activated processes of lipid peroxidation products, which are endotoxins. Increase in the serum content of lipid peroxidation products, and increase the activity of enzymes detoxify reactive oxygen species are nonspecific tests endotoxemia. It is shown that the breakdown products of lipids (aldehydes, dialdehydes, epoxides) have a damaging effect on the different structures of heart cells: proteins, nucleic acids, etc. When endotoxicosis myocardium becomes the target of secondary damage to the complex morphological and functional changes in the body.