Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

THE INFLUENCE OF ULTRASONIC EXPOSURE ON TRANSPORT OF CYTOSTATIC AGENT DEEP INTO THE TUMOR TISSUE

Frantsityants Y.M. 1 Rozenko L.Y. 1 Komarova Y.F. 1 Krokhmal Y.N. 1 Soldatov A.V. 2 Polozhentsev O.Y. 2 Guda A.A. 2 Chainikov A.P. 2
1 FSBI Rostov Scientific and Research Institute of Oncology of the RF Ministry of Health
2 NOC «Nanodimensional structure of substance» at SFEDU
Experimental studies of the depth of oxaliplatin penetrating into the tumor tissue have shown direct dependence of the preparation distribution characteristics on the mode and time of ultrasonic exposure (USE). With I=0,4 W/cm2 T=5 min, the depth is 2-3 mm and 3-4 mm with T=10 min. If I= 1,0 W/cm2 and T=5 min, atoms of platinum are registered at the depth of 4 mm, and at 5-6 mm if T=10 min. Local USE furthers penetration of the preparation deep into the tissue (along the ultrasonic waves propagation) to a greater extent and minimum spreading of the preparation in tissues surrounding the tumor. With the discovered dependence of penetrability of oxaliplatin both on USE intensity and duration, it is seen possible to obtain the required distribution of oxaliplatin depending on the clinical situation by choosing the modes of ultrasonic exposure as appropriate.