Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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SOME PHARMACOKINETIC PARAMETERS OF 5-FLUOROURACIL AND CISPLATIN IN EXPERIMENTAL INTERSTITIAL CHEMOTHERAPY

Frantsiyants E.M. 1 Komarova E.F. 1 Grechkin F.N. 1
1 Federal state budget-funded institution «Rostov scientific and research institute of oncology» of the Ministry of Health of Russia
An experimental study of intraoperative introduction of chemotherapeutic agents: 5-fluorouracil and cisplatin. In rat liver parenchyma was introduced cytostatics autoplasma incubated with peripheral blood. It is shown that introduction of chemotherapy on autoplasma deposition of 5-fluorouracil in a marked interstitial administration to 3 hours, and in serum up to 2 hours as compared to introduction in saline (up to 1 hour and 30 min, respectively). Date of deposit cisplatin were also different rats by introduction of chemotherapy and autoplasma saline (up to 7 days to 3 days). Thus, the use of autoplasma for interstitial introduction of cytotoxic drugs allows them to deposit and extend the length of stay in the region of their efficiency.