Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

SOME PHARMACOKINETIC PARAMETERS OF 5-FLUOROURACIL AND CISPLATIN IN EXPERIMENTAL INTERSTITIAL CHEMOTHERAPY

Frantsiyants E.M. 1, Komarova E.F. 1, Grechkin F.N. 1
1 Federal state budget-funded institution «Rostov scientific and research institute of oncology» of the Ministry of Health of Russia
An experimental study of intraoperative introduction of chemotherapeutic agents: 5-fluorouracil and cisplatin. In rat liver parenchyma was introduced cytostatics autoplasma incubated with peripheral blood. It is shown that introduction of chemotherapy on autoplasma deposition of 5-fluorouracil in a marked interstitial administration to 3 hours, and in serum up to 2 hours as compared to introduction in saline (up to 1 hour and 30 min, respectively). Date of deposit cisplatin were also different rats by introduction of chemotherapy and autoplasma saline (up to 7 days to 3 days). Thus, the use of autoplasma for interstitial introduction of cytotoxic drugs allows them to deposit and extend the length of stay in the region of their efficiency.

Библиографическая ссылка

Франциянц Е.М., Комарова Е.Ф., Гречкин Ф.Н. НЕКОТОРЫЕ ПОКАЗАТЕЛИ ФАРМАКОКИНЕТИКИ 5-ФТОРУРАЦИЛА И ЦИСПЛАТИНА ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ВНУТРИТКАНЕВОЙ ХИМИОТЕРАПИИ // Научное обозрение. Медицинские науки. 2014. № 2. С. 174-174;
URL: https://science-medicine.ru/en/article/view?id=501 (дата обращения: 07.06.2026).