Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

STATE OF PROOXIDANT-ANTIOXIDANT SYSTEM AND ACTIVITY OF DIGESTIVE PROTEASES IN RATS AFTER ACUTE INTOXICATION BY CARBON TETRACHLORIDE BEFORE AND AFTER CORRECTION WITH VEGETABLE OILS

Khilchuk M.A. 1 Esaulenko E.E. 1 Bykov I.M. 1
1 Kuban state medical university RF Ministry of Health
In our research we show the results of study of state antiradical protection system of blood and activity of digestive proteases (pepsin, trypsin, chymotrypsin) in homogenates of the stomach, pancreas of experimental animals (rats) that were exposed to intoxication by carbon tetrachloride. In course of study we found that there are the activation of lipid peroxidation (LPO), imbalance in enzymes of antiradical protection system (catalase and superoxide dismutase) and the decrease of pepsin, trypsin and chymotrypsin production in rats, which were poisoned by carbon tetrachloride. Using the flax oil and juglans nigra and juglans regia oils helped to reduce intensity of the processes of lipid peroxidation, to normalize enzymatic chain of antiradical protection system of blood and also tend to restore production of digestive proteases when rats have got a model of acute toxic liver injury induced by administration of carbon tetrachloride. These results create a basis for further studying and using these vegetable oils in treatment of pathological conditions after transmission different toxic agents to human body.