Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

VASCULAR ENDOTHELIAL GROW FACTOR AND POLYMORPHISM OF VEGF (RS2010963) GENE IN PATHOGENESIS OF CHRONIC HEPATITIS C

Bulatova I.A. 1
1 SBEI HPE Perm State Medical Academy named after ac. E.. Wagner
Aim of research: to explore the level of vascular endothelial growth factor (VEGF) in the serum and to evaluate the functional significance of VEGF gene polymorphism in rs2010963 sector in the pathogenesis of chronic hepatitis C (CHC). Material and methods. 100 patients CHC were examined, the control group included 70 healthy donors. Concentration of VEGF in blood was investigated by ELISA . The frequency of allelic variants of VEGF (rs2010936) and related genotypes on the analysis of melting curves obtained by polymerase chain reaction were estimated. Results. An increase in the concentration of VEGF in CHC in comparison with the control group (p = 0.001), a significant increase in the frequency of pathological CC homozygotes (х2 = 4.55, p = 0.03) were detected. A demonstrative correlation of pathologic minor allele T of VEGF (rs2010963) with the level of VEGF serum (r = 0.25, p = 0,007) were revealed. Conclusion. Adverse allelic variants of the gene, mainly due to homozygous carriers of the CC, can act as hereditary risk factors of endothelial damage in viral hepatic disease and progression of CHC. Gene VEGF (rs2010963) may be considered “candidate” genome of predisposition to CHC.