Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

HOSPITAL RELAPSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH NON-INFECTIOUS TYPE OF EXATERBATION: THE ROLE OF NOSOCOMIAL INFECTION

Chernogoryuk G.Е. 1 Denisova O.А. 1 Gudkova L.V. 1 Kurdina E.M. 1 Rachkovskiy M.I. 1 Egorova K.К. 1
1 Siberian state medical university
In comparative, prospective, non-randomized cohort study the frequency of hospital relapse of infectious COPD exacerbation was evaluated in patients hospitalized with non-infectious exacerbation of the disease; typical spectrum of sputum microflora for hospital exacerbations of COPD was defined. It was found that 57 % of patients hospitalized with non-infectious type of COPD exacerbations demonstrated relapse of infectious type exacerbation by 10–16 day of hospitalization in which initiation involved nosocomial microorganisms: Pseudomonas aeruginosa, Klebsiellapneumoniae (ESBl), Acinobacterboumonii, St. aureus (MRSA), Klebsiellaoxytoca (ESBL), E.coli (ESBL), Citrobactercoseri, Stenotrophomonasmaltophilia, Morganellamorganii. Multidrug-resistant microorganisms in patients with hospital exacerbation of COPD were more common than in patients with community-acquired COPD exacerbation (45 % and 18 % respectively). The assigned antibiotic therapy for hospitalized patients with non-infectious exacerbation did not prevent the aggravation of hospital infection.