Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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VISFATIN AND LEPTIN CONTENT RESEARCH IN BLOOD SERUM OF PATIENTS WITH METABOLIC SYNDROME. THEIR ROLE IN SENILISM DEVELOPMENT

Chernysheva E.N. 1 Panova T.N. 1
1 State budget educational establishment of higher professional education “Astrakhan state medical academy” of Ministry of health service
Visfatin and leptin content in patients with metabolic syndrome was researched. It was supposed the participation of these proteins in the process of senilism. 270 patients with metabolic syndrome at the age of 30 till 60 years old were examined (162 men and 108 women). The diagnostics of metabolic syndrome was based on the criteria suggested by experts of all-Russian scientific cardiologists’ society (2009г.). Sinilism rate index and biological age were counted due to A.G. Gorelkin and B.B. Pinkhasov formulae, visfatin (нг/мл) and leptin concentration was determined by the ELISA method. Visfatin content in blood serum at the patients with metabolic syndrome has been increased 35,8 (33,9; 48,0) нг/ml, strict positive connections between visfatin and aging rate index (r+0,7, р< 0,05); visfatin and biological age were established (r+0,78, р< 0,05). Strict positive connection between leptin and body mass index was established at the patients with metabolic syndrome (r+0,8, р< 0,05); visfatin and body mass index (r+0,96, р< 0,05), intensity of these protein output is increasing parallel to obesity intensity. In the presence of physiological senilism the visfatin and leptin content is 29,1 (27,5; 30,0) и 10,3 (8,6; 13,7) нг/ml. It differs statistically from the findings at the micromegaly – 37, 0 (34, 6; 49, 5) and 34, 5 (19, 8; 49, 3).