Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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PATTERNS OF VIOLATIONS OF IMMUNE AND CYTOKINE STATUS AGAINST NEOADJUVANT POLYCHEMOTHERAPY IN BREAST CANCER AND THEIR POSSIBLE MEDICAL CORRECTION

Chesnokova N.P. 1 Barsukov V.Y. 1 Zlobnova O.A. 1
1 State Government-Financed Educational Institution of Higher Professional Education V. I. Razumovsky Saratov State Medical University of the Russian Ministry of Healthcare Development Saratov
The authors have come to the conclusion that when talking about mechanisms of neoplastic proliferation in the breast cancer should pay equal attention to both initiating mechanisms of oncogenic transformation of cells and peculiarities of paraneoplastic disorders influencing tumor cells elimination and contributing to development of neoplastic proliferation. The authors performed hospital and laboratory examination of patients with node-positive breast cancer (T1-3N1-2M0 stages), this research discovering T- and B- lymphocyte immunodeficiency progress, increases in the blood levels of cytokines in patients at the time of admission to hospital, prior to treatment aggravated against the background of the next 6 courses neoadjuvant polychemotherapy . The use of polyoxidonium as a immunomodulator, membrane protector, detoxifier in the course of combination treatment in patients with similar stages of the disease during neoadjuvant polychemotherapy provided positive dynamics of humoral, cellular immunity, cytokine status.