Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ASSOCIATION OF GENETIC VARIANTS AT LOCUS 9P21.3 WITH LONG-TERM OUTCOMES IN PATIENT WITH MYOCARDIAL INFARCTION

Shesternya P.A. 1 Nikulina S.Y. 1 Shulman V.A. 1
1 Krasnoyarsk State Medical University n.a. prof. V.F. Voino-Yasenetsky
We have done investigation of association between 9p21.3 locus single nucleotide polymorphism (SNP) rs1333049 and long-term outcomes in patient with myocardial infarction (MI). A total of 500 patients (411 male, 89 female) with MI age younger 65 old were recruited (mean age was 53,35±7,79 years). Genotyping of SNP rs1333049 was performed using real-time polymerase chain reaction (PCR) according to protocol (probes and primers TaqMan, Applied Biosystems 7900HT). All discharged patients were divided on two groups: patients underwent percutaneous coronary intervention were included in group 1, patients received conservative treatment (incl. thrombolytic) were joined in group 2. Follow-up period lasted two years. We revealed a direct strong association of the locus 9р21.3 with worse outcomes (hospitalization due to acute coronary syndrome (ACS) and recurrent MI) in group 2 during follow-up period. Carriers of risk allele C rs1333049 had significant higher relative risk of recurrent MI during one year – 1,13 [95% CI: 1,07-1,19] and two years – 1,26 [95% CI: 1,12-1,63]. For ACS relative risk were – 1,32 [95% CI: 1,15-1,51] and 1,46 [95% CI: 1,21-1,78] consequently.