Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE MARKERS OF SYSTEMIC INFLAMMATORY RESPONSE IN ACUTE ABDOMINAL DISEASES

Akimova V.M. 1 Lutsiv N.Z. 1 Tsymbala O.P. 1
1 The Lviv national medical university named by Danylo Galitski
The analysis of cytokine regulation peculiarities and procalcitonin (PCT) concentration in acute inflammatory diseases of the abdominal cavity was held. The aim of the work was to characterize the acute inflammation model with the position of the typical pathological process. It was examined the serum levels of proinflammatory cytokines (TNF-α, IL- 6, -8,-1β) and PCT by ELISA in patients with acute appendicitis abscess (AAA, n = 40), acute gangrenous appendicitis (AGA, n =17), acute mesenteric lymphadenitis (AML, n = 27), acute calculous cholecystitis (ACC, n = 30). It was established that acute abscess inflammation is characterized by significantly higher levels of IL-6 and IL-1β, and lower levels of IL-8 and TNF-α compared to phlegmonous inflammation. As in cases of AAA and AGA significantly elevated PCT level and indicates the possibility of the development of sepsis. In AML and ACC without complications did not observe a significant increase in the concentration of cytokines, indicating that the local non-systemic inflammation occurs. The PCT levels were in the range up to 1 ng / ml, which also indicates a low probability of sepsis developing. Degree of increase in concentration of serum PCT depends collapsible complications and additional bacterial infection that we observed in patients with complicated ACC. The study of cytokine regulation features of the inflammatory process enables to predict the development of systemic inflammation, and PCT can used as a predictor of septic inflammation.