Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

THE MARKERS OF FIBROSIS AND THE ECHOCARDIOGRAPHIC PARAMETERS OF THE LEFT ATRIUM IN PATIENTS WITH ATRIAL FIBRILLATION

Vasilez L.M. 1 Ratanova E.A. 1 Grigoriadi N.E. 2 Karpunina N.S. 1 Petrusha A.V. 1 Krivaya A.A. 1 Tuev A.V. 1
1 PGMA Perm
2 Perm regional hospital
The indicators of cardiac fibrosis at patients with various forms of atrial fibrillation (recidivous, permanent) were investigated. The study included patients with different forms of atrial fibrillation in combination with arterial hypertension and without it. All patients in all groups compared with the pathology in healthy had the signs of left atrial dilatation. In this case, minimal changes were observed with idiopathic atrial fibrillation. In all patients with hypertension, there were signs of dilatation of the left atrium, but more pronounced in case of arterial hypertension in combination with atrial fibrillation. In the study of correlations with echocardiographic indicators of fibrosis parameters established that significant relationships are observed mainly in PICP measure the parameters of the left atrium. The increase in the size of the left atrium is associated with increasing of concentrations of PICP. Permanent atrial fibrillation is associated with increased of the level of PICP and with decreased of the concentration of TIMP-1. The concentration of MMP-9 does not depend on the form of atrial fibrillation.