Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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FREQUENCY OF OCCURRENCE OF A RARE FORM OF IMMUNOCHEMICAL OPTIONS IMMUNOGLOBULIN IN PATIENTS WITH MULTIPLE MUELOMA AND THEIR INFLUENCE ON SURVIVAL

Baratova D.A. 1 Baratova M.A. 2 Dzhaparkulova A.D. 3 Nurlyhanov E.B. 4
1 Eurasian Center oncohematology
2 Republican Scientific Center of Emergency Medical Assistance
3 National Hospital under the Ministry of Health of the Kirghiz Republic
4 Regional Clinical Hospital
The article presents the results of studies of rare forms of immunoglobulins, their frequency of occurrence of the most common and rare forms of immunochemical variant Ig A- myeloma, Ig E,IgA-myeloma, Ig D-myeloma patients with multiple myeloma residents of Kirghizia, which have a significant impact on patient survival. These studies are being conducted for the first time in the comparative analysis in the frequency of immunochemical version of kirghiz population and the Russian-speaking population of Kirghizia. According to the results of our study on assessing the impact of immunoglobulin class on outcome of multiple myeloma , the survival rate of patients with Ig A- myeloma, Ig D-myeloma and myeloma IgE, IgA is much lower compared with patients suffering from Ig G-myeloma. MM patients kirghiz nationality recorded in the form of immunochemical embodiment 65 % Ig A–myeloma cases, Ig D-myeloma in 1,5 % cases, IgE myeloma 0,5 % cases, and when detected early uptake of primary chronic kidney disease and myeloma Ig G-recorded in 33 % cases. Based on test results of clinical and laboratory parameters and chronic renal failure in IgA , Ig D, Ig E-myeloma compared with IgG-myeloma for more malignant disease. This requires a timely selection of therapy and chemotherapy program selection.