Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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IMMUNOGENETICHESKIE INDICATORS AND FREQUENCY OF THE CARRIER EPCHTEINA- BARR VIRUS, CYTOMEGALOVIRUS AMONG POTENTIAL DONORS OF HEMOPOETIC STEM CELLS

Baratova M.A. 1 Baratova D.A. 2, 3 Nurlyhanov E.B. 2, 4
1 Republican Scientific Center of Emergency Medical Assistance
2 National Register of hematopoietic stem cells Kirghiziа in Saint Petersburg
3 Eurasian Center oncohematology
4 Regional Clinical Hospital” Shymkent
The article presents the results of studies of immunogenetic and population characteristics of bone marrow donors in the kyrgiz ethnic group compared with healthy residents of the Northwest region of the Russian Federation of the Russian register of bone marrow. Set high significant differences were revealed significant HLA-markers in the kyrgiz nation; viruses when tested on a group of donors identified Epstein - Barr virus in 26% and 39% cytomegalovirus cases. Among potential donors of hematopoietic stem cells with chronic foci of infection revealed increased titers of immunoglobulin Ig A k, l and Ig G k,l, light chains. Thus, the observed differences in comparison with the control group raises the question of a timely selection of treatment and choice of potential bone marrow donors. At presence of HLA-identical donor use of allogeneic hematopoietic stem cell transplantation. For qualitative selection of the donor - to improve the security algorithm and a bone marrow donor. At the present stage, bone marrow transplantation provides the best results for increasing survival in the treatment of malignant diseases.