Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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IMMUNOGENETIC ASPECTS OF ANTIGENS HLA-ALLELES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX PATIENTS WITH MULTIPLE MYELOMA AND DONORS HEMOTOPOIETIC STEM CELLS

Baratova M.A. 1 Baratova D.A. 2, 3 Dzhaparkulova A.D. 3, 1, 4 Nurlyhanov E.B. 3, 1, 4, 5
1 Republican Scientific Center of Emergency Medical Assistance
2 Eurasian Center oncohematology
3 National Register of hematopoietic stem cells Kirghiziа in Saint Petersburg
4 National Hospital under the Ministry of Health of the Kirghiz Republic
5 Regional Clinical Hospital
The article presents the results of studies of immunogenetic characteristics of patients with multiple myeloma and bone marrow donors kirghiz nationality. Typing were performed in healthy donors kirghiz ethnic first in HLA-class I alleles of loci (A and B) and HLA class II alleles locus DRB1 *, in comparison with the data of patients with multiple myeloma kirghiz nationality, while there are enough highly reliable significant differences. Revealed complex laboratory methods HLA- significant markers in the kirghiz nation. Thus, the observed differences in comparison with the control population group will allow time to pick up a bone marrow donor, and apply high-tech treatments that improve survival in multiple myeloma and other hematological pathologies at an early stage of the disease.