Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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IMMUNOGENETIC MARKERS HLA-CLASS I AND II IN PATIENTS WITH MULTIPLE MYELOMA

Baratova D.A. 1 Baratova M.A. 2
1 NMU «Eurasian Center oncohematology
2 AO «Republican Scientific Center of Emergency Medical Assistance» Astana
The article presents the results of studies on the immunogenetic characteristics of the system alleles HLA- class I and II patients with multiple myeloma kirghiz ethnic group compared with the antigens HLA- alleles of class I and II patients with multiple myeloma in the Northwestern region of the Russian Federation. Complex laboratory methods revealed significant HLA- markers in patients with multiple myeloma kirghiz nation. When comparing the gene HLA -locus (A and B) and HLA - DRB1 * locus test results showed typical for patients with multiple myeloma kirghiz ethnic locus antigens HLA-(A and B ) -HLA- A28 , HLA- B13 , HLA- B17 and rarer antigens HLA- A24 , HLA- A25 , HLA- B35 and the locus HLA - locus DRB1 *, HLA-DRB1 * 0901 , HLA-DRB1 * 1001 , HLA-DRB1 * 1601 and less common HLA-DRB1 * 1401 and there are quite statistically significant differences. Thus, the observed differences in comparison with the control group population will allow for the timely selection of treatment and choice of donor bone marrow or hematopoietic stem cells.