Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ADAPTIVE CHANGES IN PARAMETERS OF OXIDATIVE STRESS AND ANTIOXIDANT PROTECTION IN THE ORAL FLUID AND BLOOD WITH COMORBID CONDITIONS

Basov A.A. 1 Gorkunova A.R. 1
1 Kuban State Medical University Krasnodar
The article presents data on changes in enzyme activity of antiradical defense (catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase) and accumulation of oxidative modifications in blood and oral fluid in people (n=105) with secondary lack of teeth and in people (n=50) with comorbid somatic pathology. Found that the most pronounced abnormalities in the prooxidant-antioxidant system observed in patients with type 2 diabetes, in which decreased activity of all enzymes in the local and systemic level, as well as the most significant increase of oxidative modification in the blood (by 181.6%) and oral fluid (by 257.7%). Results of the study show that the oral cavity are autonomous mechanisms that regulate the activity of the enzyme level of the antioxidant system, which is accompanied by an adaptive increase in activity of glutathione reductase, glutathione peroxidase, superoxide dismutase in the oral fluid in chronic generalized periodontitis.