Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ROLE OF THE SYSTEM OF ANGIOENIC FACTORS AND CYTOKINES IN THE PROGNOSIS OF PLACENTAL INSUFFICIENCY IN DEPENDENCE ON FETAL GENDER

Botasheva T.L. 1 Linde V.A. 1 Sargsyan O.D. 1 Rimashevskyi A.N. 2 Ermolova N.V. 1 Mihelson A.A. 1
1 Federal State Budget Establishment “Rostov-on-Don research institute of obstetrics and pediatrics” of Ministry of Health of Russian Federation
2 State Budget Educational Establishment Rostov-on-Don State Medical University of Ministry of Health of Russia
The article presents data on the studying of some angiogenic factors and cytokines expression in women with physiological pregnancies and in case of placental insufficiency in dependence on fetal gender. We detected that in physiological pregnancy and in case of placental insufficiency there is a definite ratio of VEGF, EGF, PGF, ET-1, TNF-a, IL-1, IL-6, IL-10 and IL-12 in dependence on fetal gender. We registered a greater level of angiogenic factors (VEGF, EGF, PGF, ET-1) and cytokines (TNF-a, IL-1, IL-10, IL-12) in women with female fetuses in 2d and 3d trimesters of both physiological and complicated pregnancies. On the basis of the results of multifactorial analysis we revealed prognostically significant triads of angiogenic factors and cytokines as well as its numerical values, allowing to make an individual prognosis of placental insufficiency development in women with alternative fetus.