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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
THE DYNAMICS OF HEPATOFIBROSIS AND ANGIOGENESIS IN PATIENTS WITH CHRONIC HEPATITIS C ON THE BACKGROUND OF ANTIVIRAL THERAPY
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Aim of the study was to investigate the dynamics of cytolysis, the process of angiogenesis, regeneration of hepatocytes, the dynamics of hepatofibrosis and virologic response on the background of antiviral therapy (AVT) in patients with chronic hepatitis C (CHC). Material and methods. 50 patients with CHC were examined. Serum levels of transaminases, the concentration of vascular endothelial growth factor (VEGF) and alpha-fetoprotein (AFP), the viral load was investigated, the severity of fibrosis was detected by fibroelastography. Results. Before the employment of AVT the increased serum level of transaminases and the increased concentration of VEGF (p=0,001) and AFP (p=0,001) in comparison with the following group were detected. The density of the liver in patients with CHC before AVT was at the average 9,5 kPa (from 3,5 to 63,9 kPa). After the employment of AVT in 74 % cases the level of transaminases decreased as well as the concentration of VEGF (p<0,001), redistribution of patients with CHC with different degree of hepatofibrosis and the reduction of the density of the liver at the average to 6,17 kPa (3,3 – 13,6 kPa) (p<0,05) took place. No significant changes of the level of AFP in patients with CHC on the background of AVT were observed (p=0,5). The immediate virologic response came to 90 %. Conclusion. At the reactivation phase of CHC we observe endothelial damage, growing process of angiogenesis and regeneration of hepatocytes. Combined AVT leads to decrease in cytolysis of hepatocytes, reduction of neoangiogenesis activity and to an improvement in liver’s elastographic rates.