Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ANTIOXIDANTS IN INCREASING DETOXIFYING BODY’S ABILITY TO

Vlasov A.P. 1 Gashimovа S.K. 1 Abramova S.V. 1 Polozova E.I. 1 Turygina S.A. 1 Mesickov O.I. 1
1 Mordvinian State University
In this paper we assess the efficiency of metabolic drugs and the type of action etoksidol and mexidol correction of endogenous intoxication in acute peritonitis. It is shown that in acute experimental peritonitis application of a new derivative of 3 - hydroxypyridine etoksidol dose of 10 mg/kg resulted in a decrease in endogenous intoxication, due to its ability to increase the barrier function of the intestines and liver detoxification ability. Pharmacological activity etoksidol dose of 10 mg/kg to raise the status of the body detoxification at acute peritonitis is not inferior to that of the same dose mexidol. One of the mechanisms of action of the detoxification of 3-hydroxypyridine and etoksidol and mexidol at acute peritonitis is their ability to reduce tissue structures in the intestine and liver effects of oxidative stress, thereby exhibit membrane stabilizing action.