Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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PATOGENETIC APPROACH IN PREVENTING LIPID DESTABILIZATION IN ACUTE PANCREATITIS

Vlasovа Т.I. 1 Gulyaevа L.R. 1 Leshchankinа N.Y. 1 Turyginа S.A. 1 Vlasov P.A. 1 Loginov M.A. 1
1 Mordvinian State University
The paper presents the results of an experimental study of the effect emoxipine, verapamil and a proactive reamberin their introduction on the inflammatory process, changes in the qualitative and quantitative composition of the lipid tissue structures of the pancreas, the intensity of lipid peroxidation, antioxidant capacity and the activity of phospholipase A2 in acute pancreatitis. It is shown that the preventive use of investigational drugs before simulating acute biliary pancreatitis can reduce the severity of inflammation in the tissues of the pancreas. This is due to a sharp increase in the prevention of free-radical processes of lipid peroxidation, increased phospholipase activity, increase of hypoxic processes, which resulted in less destabilization of the lipid composition of biological membranes pankreatotsitov. It has been established that the studied drugs in their preliminary application significantly reduces the severity membranodestruktivnyh processes in the cells of the pancreas with simulated acute pancreatitis, as evidenced by the decrease was not only the centers of pancreatic necrosis , but less pathological transformation of phospholipid composition of biomembranes organ cells.