Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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PROVISION OF VITAMIN D, INDICATORS CALCIUM AND PHOSPHORUS METABOLISM, PARATHYROID FUNCTION IN PATIENTS WITH SYNDROME SECONDARY HYPEROXALURIA AT EARLY STAGES OFCHRONIC KIDNEY DISEASE

Voroninа N.V. 1 Agievich T.B. 1
1 Far Eastern State Medical University
There was performed an analysis of vitamin D, calcium and phosphorus metabolism, parathyroid function in the early stages of chronic kidney disease (CKD) in patients aged 18 to 40 years, with a syndrome of secondary hyperoxaluria and tubulointerstitial disorders. There was later performed the investigation of 25 hydroxyvitamin D [25 (OH) D3], parathyroid hormone (PTH), total calcium, phosphorus, total alkaline phosphatase, creatinine, with calculation of glomerular filtration rate by the formula Cockroft-Gault, the daily excretion of calcium. Patients with stage 1–2 CKD marked decrease in total serum calcium in normal daily excretion of calcium, increased total alkaline phosphatase, and a moderate increase in parathyroid hormone. These changes can lead to the development of osteopenia syndrome. Level 25 hydroxyvitamin D [25 (OH) D3] and phosphorus in the blood serum did not differ from that of a group of healthy individuals.