Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE RISK OF NEUTROPHILIC BRONCHI INFLAMMATION DEVELOPING AMONG CHILDREN AFFECTED BY BRONCHIAL ASTHMA AND DELETION POLYMORPHISM OF GSTT1 AND GSTM1 GENES

Galuschinskaya A.V. 1
1 Bukovinian State Medical University
In this work the connection of polymorphism of GSTT1 and GSTM1 genes and the nature of bronchial inflammation among children, who suffer from bronchial asthma is researched. It was ascertained that patients with neutrophilic character of imflammation are more frequently to be observed with deletion polymorphism of GSTM1, whereas those with pautsyhranulotsytarny variant of inflammation are characterized by genotype T+ M+, and eosinophilic – with equal distribution of GSTT1 and GSTM1 genotypes. When combining deletion polymorphism in one of the GST subpopulations or in both genes (T1delM1+, T1+M1del, T1delM1del) is was established the probable risk of netrophilic type imflammation of the bronchial tree among children who suffer from asthma (RR=1,6, 95%CI: 1,3-2,0 in AR=0,21).