Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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OBTAINING A STABLE IMMOBILIZED FORM OF CARDIOLIPIN AS METHOD INDUSTRIAL SYNTHESIS OF ANTIGENIC NANOOBJECTS

Gontar I.P. 1 Emelyanova O.I. 1 Paramonova O.V. 2 Krasilnikov A.N. 2 Trubenko Y.A. 2
1 Scientific-Research Institute of Clinical and Experimental Rheumatology
2 Volgograd State Medical University
On the basis of integration antigenic properties, we have created and tested immobilized magnetic antigenic nanosystems. They represent a polyacrylamide granules with included in their structure of the antigen. Most interesting in this respect, it seems to us, as a model, antigenic preparation - cardiolipin. To obtain a stable immobilized biological reusable with specified properties (shape, particle diameter, pore size, density), we used the method of emulsion polymerization in our modifications using polyacrylamide gel as the carrier. This method made it possible to significantly increase the sorption capacity, to keep the antigen in the most native state and opened up the possibility of controlled modification.