Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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MORPHOMETRY OPTIONS AND THE IMMUNOHISTOCHEMICAL MARKERS OF FIBROSIS AND INFLAMMATION IN THE EARS ATRIUMS IN PATIENTS WITH ATRIAL FIBRILLATION OF DIFFERENT ETIOLOGY

Grigoriadi N.E. 1 Vasilez L.M. 2 Tuev A.V. 2 Kosareva P.V. 2 Latysheva S.Y. 3 Gordiichuk R.N. 4 Scherbenev V.M. 4
1 Permskaya Regional Clinical Hospital
2 Perm State Medical Academy. ak. EA Wagner
3 Regional Hospital RZD
4 Permskaya Regional Clinical Hospital № 2 «Heart Institute»
Studied the morphometric characteristics and severity of tissue expression of markers of fibrosis and inflammation in atrial myocardium by immunohistochemistry in patients with different forms of atrial fibrillation , including arterial hypertension and coronary heart disease progression . The main group included biopsies of the atrial appendages of 55 patients with atrial fibrillation of different etiologies. Atrial endocardial fibrosis ears begin to form , smiling in patients with idiopathic atrial fibrillation , progressing in patients with arterial hypertension and atrial fibrillation , and reach a maximum in the group with coronary artery disease , hypertension and AF. In the tissues of the atrial appendages revealed increased expression of immunohistochemical markers of inflammation and fibrosis . Expression of matrix metaloproteninazy -9 and tumor necrosis factor -α progressively in-creases in patients with hypertension and its combination with coronary artery disease .