Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CHARACTERIZATION OF COLLAGEN METABOLISM IN THE BONE TISSUE OF RATS WITH ALLOXAN DIABETES UNDER CONDITIONS OF HYPOCORTICOIDISM

Danilova O.V. 1 Savinova N.V. 1 Butolin E.G. 1 Perevedentseva S.E. 1 Vyatkin V.A. 1
1 Ishevsk State Medical Academy
In this article were presented the results of the study indicators of the collagen metabolism in the bone tissue of rats with alloxan diabetes and combined alloxan diabetes with the introduction of the synthesis of the blocker of corticosteroids. In the tissue of the vertebrae were determined the levels of free hydroxyproline, total collagen, his neutralsaltsoluble fraction, collagenase activity at 5, 15, 20, 30 and 45 days of the experiment. In the exchange of collagen at rats with alloxan diabetes in the first 30 days of the experiment the rezorbtivee processes dominated over the synthetic; on the 45 day of the experiment was indicated the increase of activity of the catabolic processes. Analyses of metabolism bone collagen of animals with alloxan diabetes, under conditions of hypocorticoidism showed on the oppression of the catabolism collagen in the spongy bone with simultaneous strengthening of synthetic reactions.