Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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FEATURES OF FREE-RADICAL OXIDATION IN THE LIVER IN EXPERIMENTAL MODELING OF PTSD

Deev R.V. 1 Telesheva I.B. 1 Zvorygin I.A. 1 Bayburina G.A. 1 Agletdinov E.F. 1 Galiullina I.G. 1
1 South Ural state medical university
Posttraumatic stress disorder accompanied by an extremely high frequency of comorbidities, include coronary heart disease, hypertension, stroke, and liver disease. Given the crucial role of the liver in the livelihood of the body, liver dysfunction may be the main manifestation of somatic pathology and exacerbate the severity of other comorbidities. The main factors leading to the formation of somatic pathology in posttraumatic stress disorder, is now considered a endocrine status changes, inevitably accompanied by the activation of free radical oxidation. Therefore, the study of oxidative stress as factors involved in the pathogenesis of various neuropsychiatric diseases and their complications - one of the most urgent problems of medical biochemistry. The study was performed on 40 albino laboratory rats. At different periods of experimental modeling of PTSD studied the content of the main categories of products of free radical oxidation in the liver. It is shown that the main manifestation of oxidative stress in the liver is increased oxidative modification of proteins in the body, which may cause its dysfunction.