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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
THE PREDICTIVE IMPORTANCE OF COMBINATIONS OF GENETIC OPTIONS INTERLEYKINOV IN DEVELOPMENT OF CHRONIC KALKULEZNY CHOLECYSTITIS
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The analysis of communication of combinations of genetic polymorphisms of interleykin to formation of the chronic kalkulezny of cholecystitis (CKC) was carried out on selection of 544 people: 250 sick HKH and 294 people of population control who are natives of the Central Chernozem region of Russia. As material for research the blue blood of 4–5 ml served. Allocation of genomic DNA from peripheral blood was carried out by method of phenolic and chloroformic extraction. The allocated DNA was used for carrying out polimerazny chain reaction of synthesis of DNA. It is established that a carriage at men of alleles - 511T IL-1B, - 584T IL-4, - 113T IL-9 and a genotype - 511TT IL-1B, and also combinations of genetic markers: - 889T IL-1A, - 511T IL-1B and - 703C IL-5; - 511T IL-1B and - 703C IL-5; - 889T IL-1A, - 511T IL-1B and - 584T IL-4; 889T IL-1A and - 511T IL-1B causes the increased risk of development of HKH. Existence at women of combinations of genetic options - 889TT IL-1A, - 511T IL-1B and - 113T IL-9; - 511T IL-1B, - 703C IL-5 and - 113TT IL-9; - 511T IL-1B, - 113T IL-9, - 592C IL-10 and - 251T IL-8; - 511T IL-1B, - 703T IL-5 and - 584C IL-4 defines risk of formation of HKH, and existence of combinations - 889C IL-1A, - 511C IL-1B and - 703C IL-5; - 511C IL-1B and - 703C IL-5 possesses protective action.