Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE INFLUENCE OF DOPAMINE ON WATER SECRETORY FUNCTION OF KIDNEYS AT EXPERIMENTAL RAPID KIDNEY INSUFFICIENCY

Dzhioev I.G. 1 Hubulov I.G.1 1 Batagova F.E. 1 Klochkov D.A. 2
1 North Ossetian State Medical Academy
2 Branch № 3 of Federal public commercial institution “1602 Military and clinical hospital” Ministries of Defence of Russia (362000
Despite the different opinions on appropriateness of use of dopamine at renal pathology the purpose of the real work was the experimental studying of its effects at the sharp kidney insufficiency created on the Vistar rats by single introduction of glycerin in a dose of 0,8 ml/100 g, both causing an exudative glomerulopathy and dystrophic and necrotic changes of tubules of kidneys, a proteinuria, decrease of diuresis as a result of suppression of renal blood flow and speed of a glomerular filtration, increase of the content of creatinine in blood plasma. Quadruple intraperitoneal introduction of dopamine within one hour to rats in a dose of 2,5 mkg/kg/min. increases the volume of renal blood flow, speed of a glomerular filtration and water diuresis, but doesn’t influence on tubular reabsorption of water, the content of creatinine, urea and general protein in blood plasma and their excretion with urine. Introduction against sharp kidney insufficiency of dopamine reduces functional manifestations of pathology, but has no impact on morphological changes of kidneys.