Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ADHESION MOLECULE EXPRESSION ANALYSIS ON TYPE II DIABETES MELLITUS PATIENT NEUTROPHILS

Dolgushin I.I. 1 Tarabrina Y.O. 1 Kolesnikov O.L. 1 Kolesnikova A.A. 1
1 SouthUrals State Medical University
Adhesion molecule expression analysis on type II diabetes mellitus patient neutrophils (DM2) and on patients with diabetic foot (DF) syndrome was studied. Leukocyte quantity increased only in patients with DF syndrome. DM2 presence resulted in decreasing of relative and absolute neutrophil quantity with CD 16 + 11b + and CD 16 + 11b + 66b+ phenotypes. CD 62L, CD 11b and joint CD 62LCD 66b, CD11bCD 66b expressions reduced in patients with CD11bCD 66b group. After additional stimulation with phorbolmiristatazetat in DM2 group absolute cell quantity with CD 16 + 66b + phenotype increased statistically considerably almost twice. Neutrophil number with CD 16 + 62L +, CD 16 +62L+66b+, CD 16+11b+66b+ phenotypes increased in comparing with the ones in DM group. Presence of DM syndrome resulted in increasing (in comparison with DM2 group) the cells, the membrane of which CD 16+62L+, CD 16+11b+, CD 16+62L+66b+, CD 16+11b+62L+ were presented. The data obtained show the decrease of functional neutrophil activity in DM2 and DF syndrome. However, the cells of these patients have undoubtedly a more expressed functional reserve.