Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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NEUTROPENIA AT PATIENTS WITH CHRONIC HEPATITIS C, WHO ARE RECEIVING COMBINED ANTI-VIRUS THERAPY. THE SYMPTOMS, AND THE FEATURES OF PATHOGENESIS

Dontsov D.V. 1 Ambalov Y.M. 1 Mamedova N.I. 1
1 Rostov State Medical University
Purpose: to study some features of neutropenia pathogenesis at patients with chronic hepatitis C, who receives combined anti-virus therapy. Materials and methods: in this research we had 228 patients, who were receiving combined anti-virus therapy of chronic hepatitis C. We executed special researches: automatic hematological analysis, electronic microscopy of blood cells, studying of neutrophils migratory activity and skins рН, definition of level auto-antibodies сANCA and рANCA, concentration of human G-CSF, and the frequency of gene R to G-CSF mutations. Results: it has been established, that at patients with a chronic hepatitis C during combined anti-virus therapies occur changes of endocellular structure neutrophils, their migratory activity, skins рН and G-CSF concentration. High frequency of a mutation «G/С» G911С (rs201991840) is determined too. Summary: these results we plan to use at the future for creation of method forecasting of development neutropenia at patients with chronic hepatitis C, who receives combined anti-virus therapy.