Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

SIGNIFICANCE OF DETERMINATION OF HOMOCYSTEINE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Voynova Y.V. 1 Kozlova L.K. 1
1 Orenburg State Medical Academy
We have studied the feasibility of determination of homocysteine in the blood serum of patients with systemic lupus erythematosus. Although the level of homocysteine in the average for the group was slightly lower than the recommended rate, in about half of patients with hyperhomocysteinemia had elevated levels of homocysteine. Most of our patients had moderate hyperhomocysteinemia. Only half of the patients with systemic lupus erythematosus with hyperhomocysteinemia had atherosclerotic process. Homocysteine was elevated because of the presence of antiphospholipid syndrome and thrombosis. It was not possible to establish the cause of hyperhomocysteinemia in some patients We found significant correlations between the level of dependence of homocysteine and indicators of diastolic function of the left ventricle, the level of low-density lipoproteins and blood pressure value. Also significant positive correlation between homocysteine levels and the activity of the underlying disease on a scale SLAM was revealed.