Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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MORPHOLOGICAL CHANGES FEATURES OF GASTRIC MUCOUS MEMBRANE IN CHRONIC GASTRODUODENITIS DEPENDING ON CATT-POLYMORPHISM MACROPHAGE MIGRATION INHIBITORY FACTOR

Dudnikova E.V. 1 Chernova M.S. 1 Zaz’yan V.G. 1 Besedina E.А. 1 Badian A.S. 1 Zasian E.V. 1 Аzieva N.U. 1
1 State Educational Institute of High Professional Training «Rostov state medical University» of Russian Federation Health Ministry
The relationship of gene polymorphism of macrophage migration inhibitory factor (MIF) and morphological changes in gastric mucous membrane are analyzed (GMM). 6/6 CATT-genotype was the most common. The increasing of CATT repetitions number to 1 results in risk increase of chronic inflammatory diseases of digestive tract upper part (to 3.8 times on average), the formation of high degree activity gastritis (to 2.7 times), atrophic changes development (to 2.3 times), dystrophic changes of gastric mucous membrane development (to 2.5 times). The increasing of repetition frequency in MIF genotype is associated with the development of more severe morphological changes of gastric mucous membrane and contributes to the increase Helicobacter pylori (H. pylori) risk infection. 7/7 genotype was associated with a moderate activity degree of gastritis, H. pylori “++”, the development of atrophic, dystrophic, sclerotic changes, and, on the contrary, in using 5/5 number of repetitions those ones were absent. These findings obtained during our observations indicate high significance of MIF as a biomarker of severe coarse and unfavorable outcome of H. pylori-associated gastritis.