Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

FEATURES OF IMMUNOLOGICAL REACTIVITY AND PROOXIDANT-ANTIOXIDANT STATUS OF PATIENTS WITH HORMONE THYROID DYSFUNCTION

Dydyshko E.I. 1 Basov A.A. 1 Panasenkova Y.S. 1 Pavluchenko I.I. 1
1 Kuban State Medical University Krasnodar
The study is based on data from the study, which included 79 patients with hormonal dysfunction of the thyroid gland. Cytokine profile assessed for IL-8, tumor necrosis factor-alpha (TNF) and IL-10. The control group is consisted of healthy donors(n = 32). It is established that patients observed a decrease in observed blood levels of thiol antioxidant activity and reduced erythrocyte plasma hypothyroidism 52.3% and 61.0%, respectively (p <0,05) and 66.3% and 75.1% , respectively (p <0,05) relative to the level in hyperthyroidism control group. Increased intensity and OMB SRO reactions accompanied by an increase in blood plasma MVHL 4.37 times in hypothyroidism and hyperthyroidism 4.56 times (p <0.05). PVHL observed increase in hypothyroidism and hyperthyroidism at 196.5% and 372.4%, respectively (p <0.05). All this points to a marked imbalance in the system pro - / antioxidants observed in patients with a clear predominance of non-enzymatic level. TNF - the most sensitive marker of immune disorders and IL-8 had direct correlations with indicators of prooxidant factors rFNOα / (PVHL, TBCH) = 0.45 and 0.33, respectively, rIL8/ MVHL = 0.36. Whereas these proinflammatory cytokines relationship with indicators of the antioxidant system was predominantly feedback: rFNOα / (SH-group AOA) = -0.48 and -0.50, respectively, rIL8 / (SH-group AOA) = -0.39 and -0.34 respectively.