Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CARDIOPROTECTIVE EFFICIENCY OF 3-OXYPIRIDINE SUCCINATE AND 3-OXYPIRIDINE ADIPINAT IN EXPERIMENTAL ACUTE HEART FAILURE

Zamotaeva M.N. 1 Inchina V.I. 1 Chairkin I.N. 1 Drozdov I.A. 1 Kuzmichev N.D. 1 Kuznetsov U.V. 2 Raginov I.S. 3
1 Mordovian N.D. Ogariov State University
2 Biochemical Physics Emmanuel N.M. Institute Russian Academy of Sciences
3 Kazan State Medical University
The 3-oxipiridine succinate and 3-oxipiridine adipinat cardioprotactive activity has been experimentally investigated at a acute heart failure in rats. The 3-oxipiridine succinate in a doze of 50 mg/kg is revealed to possess an appreciable cardioprotactive effect resulting in diminishing the risk and myocardium necrosis zones, as well as in decreasing morphological changes in these zones in the form of a considerable decrease in intratissual and perivascular oedema. This effect also resulted in the absence of hemorrhage and in lesser manifestation of cell infiltration as compared to the control group of the animals. The 3-oxipiridine adipinat in a doze of 80 mg/kg showed a less appreciable efficiency in comparison with the 3-oxipiridine succinate resulting in a less substantial decrease in the ischemia and necrosis areas together with the conservation of hemodynamics disorders at acute myocardium infarction.