Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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APPLICATION OF MATHEMATICAL APPROACH MAKING THE ASSESSMENT OF ANTIBACTERIAL ACTIVITY OF ARGENTIFEROUS PREPARATIONS

Igidbashyan V.M. 1 Zudina I.V. 2 Bulkina N.V. 3 Kitayeva V.N. 3 Siritsina V.S. 2 Zyulkina L.A. 1
1 Penza State University
2 Saratov State University n.a. Chernyshevsky
3 Saratov State Medical University n.a. V.I. Razumovsky
The main component of inflammatory periodontics treatment is antibacterial chemotherapeutic compounds. However, regular and long-term use of antibiotics is accompanied by simultaneous onsets of strains of microorganisms resistant to them, and there is also a development of numerous side effects. In this regard, the aim of this research was a comparison between antibacterial activity of argentiferous preparations and chlorhexidine bigluconate antiseptics that is applied rather widely in the therapeutic regimen of a generalized periodontitis. The undertaken microbiological research revealed an existence of stain distinctions in antibacterial activity of argentiferous preparations. The best results were shown by the preparations of cluster silver “Vitargol” and “Argogel” (LLC SPC Vektor-Vita, Novosibirsk, RF), however, all tested preparations had significantly less activity than 0,02% chlorhexidine solution. The mathematical apparatus applied in this work for data processing by diffusion method in an agar offered by S.E. Yesipov and his coauthors (1998) turned out to be very effective and allowed to reduce significantly the experimental bulk for receiving statistically significant results of antibacterial activity comparison of argentiferous preparations.