Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

QUANTITATIVE ANALYSIS OF HBSAG, AS A NEW MARKER FOR THE DIAGNOSIS OF INACTIVE CARRIERS

Garaguluya E.V. 1 Mazurchik N.V. 1 Khafisova O.O. 1 Ogurtsov P.P. 1
1 Centre for the liver researches and hospital medicine department school ofmedicine faculty People’s Friendship University of Russia (Russia
It is very important to define categories of inactive HBsAg carriers (IC), as these patients do not require treatment and need only dynamic observation. The role of HBsAg level for the diagnosis of IC is studied. The quantification of HBsAg (HBsAg quant) level was an innovation in identifying markers of hepatitis B. Based on the analysis of 187 patients characteristics of the diagnostic method were calculated. The positive predictive value was 88% on ALT less than 40 IUl and HBsAg quant less than 2000 lU ml, 90% on HBsAg quant 1000 lU ml , and 91% on HBsAg quant less than 300 lU ml (hepatitis Delta and other factors of hepatitis were excluded). The specificity of these indices were 70%, 81 % and 89 % respectively. When ALT reduced to 30 lU l and the positive predictive value was 90% on HBsAg quant less than 2000 lU ml, 92% on HBsAg quant less than 1000 lU ml and up to 95% on HBsAg level less than 300 lU ml. The specificity of these indices were 78%, 86 % and 95 % respectively. The obtained data allow us to recommend the definition of HBsAg quant in clinical practice for the diagnosis of IC.